A Latgalian hill fort is known to have existed at Rēzekne from the 9th to the 13th centuries, until its destruction at the hands of German crusaders of the Livonian Order. In 1285, the knights built a stone fortress on the site, which is today known as Rēzekne castle ruins, to serve as a border post on their eastern frontier.
The name Rēzekne was first documented in 1285. Throughout its early history, Rēzekne was attacked many times by Russian and Lithuanian forces. The town became part of the Polish–Lithuanian Commonwealth after the Peace of Jam Zapolski in 1582 during the Livonian War.Rēzekne received Magdeburg rights from Poland in the 17th century, but fell to the Russian Empire during the Partitions of Poland. In 1773, Rēzekne received city rights.
During the 19th century, the arrival of the Moscow-Riga and Saint Petersburg- Warsaw railways transformed Rēzekne from a sleepy country town into an important city with two stations.
In the spring of 1917, the first congress of Latgalia was held in Rēzekne, in which Latgale decided to unite with the rest of Latvia. Following Latvia's declaration of independence in 1918, and the driving out of both the German and Red armies from Latvia, the city became a cultural centre for all of Latgale.
Rēzekne was heavily damaged by both Nazi and Soviet armies during World War II; after heavy air-bombing by Soviet forces in 1944, 2/3 of its original buildings were completely destroyed. Out of a pre-war population of 13,300, only 5,000 people remained in the city at the end of the war.
Rēzekne was rebuilt after the war with an emphasis on industrial development. Rēzekne had the 5th highest industrial output in the Latvian SSR, including a dairy processor, lumber mill, and electric-instrument factory. During this time, many Russians moved to the city, making up the majority share of the population (48.5% in 2007)
