Palamuse is a small borough in Jõgeva County, Estonia, located about 12 km southeast of the town of Jõgeva. It is passed by the Amme River. With a population of 551 (as of 1 January 2011) Palamuse is the biggest settlement and the administrative centre of Palamuse Parish.
Palamuse is best known for being depicted in the Oskar Luts' 1912–1913 novel Spring (Kevade) as the settlement called "Paunvere". The 1969 film adaptation Spring was also set in Palamuse.
Palamuse was first mentioned in a letter by Pope Gregory IX on 20 November 1234. The settlement evolved around the Palamuse St. Bartholomew's Church which was built in 1234 by the monks of the Kärkna Abbey. The church was recontructed in Gothic style in the 15th century. Tower was added in the 19th century. In 1929 the church gained its today's interior