Berkeley is the location of a number of nationally prominent businesses, many of which have been pioneers in their areas of operation.
• Peet's Coffee opened its first store in Berkeley, at Vine and Walnut Street, which is still operating. Its corporate headquarters and roasting plant are located in nearby Alameda.
• Chez Panisse – founded in 1971 and the birthplace of California cuisine.
• The Freight and Salvage – founded in 1968, this is a nonprofit musical performance venue that primarily hosts folk music and world music acts
• Acme Bread Company, one of the earliest artisanal bakers in the Bay Area.
• The Cheese Board – founded in 1967/71, this business comprises two collectively owned and operated businesses.
• The Claremont Resort – founded in 1906, this historic site was originally the Claremont Hotel. Although the main hotel building lies entirely within the city limits of adjacent Oakland, a portion of the grounds lie within Berkeley, and the resort uses this for its street address.
• 924 Gilman – founded in 1986, this is an all-ages, non-profit, collectively organized music club where Berkeley natives Operation Ivy, Pansy Division, Green Day, Rancid, Crimpshrine, Tiger Army and AFI started out.
• Dark Carnival Bookstore – one of Berkeley's two science fiction and fantasy bookstores
• The Other Change of Hobbit – one of Berkeley's two science fiction and fantasy bookstores, first opened in 1977.
• Caffe Mediterraneum – Allen Ginsberg wrote part of Howl at "Caffe Med."
• The supermarket chain Grocery Outlet is based in Berkeley.
• Cleis Press, a feminist and woman centered publishing company, moved from Minneapolis