Apalachicola is a city in Franklin County, Florida, on US 98 about 80 miles (130 km) southwest of Tallahassee. The population was 2,334 at the 2000 census. The 2005 census estimated the city's population at 2,340. Apalachicola is the county seat of Franklin County.
"Apalachicola" comes from the Apalachicola tribe and is a combination of Hitchiti Indian words "apalahchi," meaning "on the other side," and "okli," meaning "people". In original reference to the settlement, it probably meant "people on the other side of the river." Many inhabitants of Apalachicola, however, choose to translate the name of their town as "land of the friendly people