Trade with Burma constitutes the largest portion of Mae Sot's economy. It has an established market for commodities such as wholesale gems and teak. Most of the towns service industries are supported by Burmese migrants who fill positions within sweat-shops and factories throughout the region. The town also suffers from a black market in illegal smuggling, people trafficking and narcotics. The Thai-Myanmar friendship bridge, is the primary gateway for trade with Burma. The border region, located several kilometres from central Mae Sot includes the Rim Moei Market that deals in imported goods and woodwork.
Mae Sot also serves as a minor tourist destination, primarily used for those wishing to visit Myawaddy in Burma or as a stopover on the way to Amphoe Umphang, popular for trekking