Mendrisio is a municipality in the district of Mendrisio in the canton of Ticino in Switzerland.
Mendrisio is the seat of the Accademia di Architettura of the university of Italian speaking Switzerland (USI).
The municipality was boosted in size on 4 April 2004 when it incorporated the former municipality of Salorino. On 5 April 2009 it incorporated the former municipalities of Arzo, Capolago, Genestrerio, Rancate and Tremona.
Mendrisio is served by Mendrisio railway station