The river valley of today's Muleg� was discovered in 1702 by the Jesuit Father Juan Maria de Salvatierra as a place for a mission and consequently for a settlement. The valley of the then-unnamed river was ideal for a mission and a settlement, because of its abundance of water.
In 1754 Father Francisco Escalante started the construction of the mission. Years later many other Jesuit fathers came into today's area of Muleg� to bring the Catholic faith and convert the natives to Catholicism
