Sansepolcro, formerly Borgo Santo Sepolcro, is a town and comune in Tuscany, Italy, in the province of Arezzo.
Situated on the upper reaches of the Tiber river, the town is the birthplace of the painters Piero della Francesca, Raffaellino del Colle (a pupil of Raphael) and Angiolo Tricca. It was also the birthplace of the Italian mathematician Luca Pacioli.
Today, the economy is based on agriculture, industrial manufacturing, food processing and pharmaceuticals. It is the home of Buitoni pasta, founded by Giulia Buitoni in 1827