Daily overnight ferries run from Trapani in Sicily, running more frequently alongside hydrofoils in Summer. Hydrofoil from Mazara del Vallo twice daily. See SIREMAR and Ustica Lines.
Planes fly in daily from Palermo and Trapani (40 minutes). See AirONEand Meridiana.
Direct Flights from Rome and Milan. A new agreement with the hotels on Pantelleria has created a long period of direct flights to Pantelleria from Rome and Milan. These flights are on big jets (300 seats or more), only on weekends, 3 or 4 times each weekend day. Usually ALITALIA fly from Milan Linate and Rome Fiumicino from June to September. You can book and buy tickets on alitalia's own site. Another company that offer seasonal flights is Blu Express It generally departs from Rome Fiumicino and Milan Malpensa. The scheduled flights are released every year in April / May. Lastly there are some charter flights, but are not very reliable as they change often their schedule and it is too risky to make a connection with them