Economically, Khargone is dependent on agriculture, with several other industries developing in the area.
The major cash crops of Khargone District are cotton and chilly (or "chili pepper"). The district is India's biggest cotton-producing region. The red chilly is exported abroad. A famous mandi of chilly at Bedia is located about 50 km from Khargone and the famous Sendhwa cotton hub is just 70 km from district headquarters
