The earliest known inhabitants of Panama were the Cuevas and the Coclé tribes, but they were massacred and wiped out by Spanish who arrived in the 16th century.
Pre-Columbian period
The Isthmus of Panama was formed in a very long process that started 20 million years ago, up to about 3 million years ago when the isthmus finally closed and plants and animals gradually crossed it in both directions (Mayo 2004: 9–10). Dolores Piperno (1984) has located the human occupancy of the isthmus at around the Late Glacial Period (cited in Mayo 2004: 13). Olga Linares ( points out in turn that the existence of the isthmus had an impact on the dispersal of people, agriculture and technology throughout the American continent from the appearance of the first hunters and collectors to the era of villages and cities (cited in Cooke and Sánchez 2004: 3).
Richard Cooke and Luis Sánchez (2004: 4, 41–42) emphasize the permanence of peoples in the terrestrial bridge of Western America, and the higher probability that Pre-Columbian peoples in the isthmus satisfied their needs by the exchange of goods, by commercial exchange and through social relationships with neighbouring communities, rather than by long distance exchanges (Cooke and Sánchez 2004: 41).
Dendrograms proposed by genetists and linguists and available information about styles and iconography of ceramic and stone objects point to a successively complex dispersal of a population of millenary permanence in the isthmus and neighbouring areas (see, for example, Corrales 2000, cited in Cooke and Sanchez 2004: 39). Cooke and Sánchez (2004: 4) argue therefore that Panama is a singular example of diversity and endemism, and that Christopher Columbus' observations (1501–02) that "although dense, every (village) has a different language and they don't understand one another" (quoted in Jane 1988) describe the ethnographic phenomenon of scattering and diversification of peoples that had
