Miltenberg lies on the railway line from Aschaffenburg to Wertheim (Main Valley Railway). Moreover, the Madonnenlandbahn branches off here towards Seckach. There are hourly connections to Aschaffenburg by day. In 1977, Deutsche Bundesbahn shut the end-of-line station right near the town (Miltenberg Hauptbahnhof) and replaced it with a through station on the other side of the river.
Miltenberg is linked to the urban agglomerations in Hesse, where many inhabitants work. Until 2008, the town bypass, which had been discussed and planned for more than 25 years was being completed. The building-cost financing, a sum of �55,000,000, was afforded for the first time ever in Bavaria through the so-called public-private partnership model
