Trains from Ghent and Antwerp run three to four times every hour, taking 20-30 minutes. Trains from Leuven/Mechelen run once an hour, taking one hour. From Brussels there is - no more - direct train, but it is very easy to go via Antwerp or Ghent, changing trains there. It is also possible to change trains in Mechelen or Dendermonde, which both have very regular connections coming from Brussels and an onward connection to Sint-Niklaas once every hour. The trip from Brussels takes around 1 hour if the connection goes smooth. Finally, there are also direct trains to Sint-Niklaas from the coast (Oostende) via Bruges (once an hour, takes 1 hour), and Lille Flandres in France (once an hour, takes 90 minutes)
