The history of the Tepebağ tumulus in the middle of Adana dates to the Neolithic Period, 6000 B.C., and the time of the first human settlements. It is considered to be the oldest city of the Çukurova region. A place called Adana is mentioned by name in a Sumerian epic, the Epic of Gilgamesh, but the geography of this work is too imprecise to identify its location.
According to the Hittite inscription of Kava, found in Hattusa (Boğazkale), Kizzuwatna was the first kingdom that ruled Adana, under the protection of the Hittites by 1335 BC. At that time, the name of the city was UruAdaniyya, and the inhabitants were called Danuna. Beginning with the collapse of the Hittite Empire, c. 1191-1189 BC, invasions from the west caused a number of small kingdoms to take control of the plain, as follows: Kue Assyrians, 9th century BC;Persians, 6th century BC; Alexander the Great in 333 BC; Seleucids; the pirates of Cilicia; Roman statesman Pompey the Great; and the Armenian Kingdom of Cilicia (Cilician Kingdom).
The history of Adana is intrinsically linked to the history of Tarsus; they often seem to be the same city, moving as the neighbouringSeyhan River changed its position. Their respective names also changed over the course of the centuries. Adana was of relatively minor importance during the Roman's influential period, while nearby Tarsus was the metropolis of the area. During the era of Pompey, the city was used as a prison for the pirates of Cilicia. For several centuries thereafter, it was a waystation on a Roman military road leading to the East. After the permanent split of the Roman Empire in 395 AD, the area became a part of the Byzantine Empire, and was probably developed during the time of Julian the Apostate. With the construction of large bridges, roads, government buildings, irrigation and plantation, Adana and Cilicia became the most developed and important trade centers of the region. Ayas (today Yumurtalık), and Kozan (formerly Sis) were
