Montepulciano is a city in Tuscany famous for its wines, especially the classic red wine Vino Nobile di Montepulciano.
Montepulciano is a few miles from the A1 Autostrada as well as the more scenic SS2 from Rome to Florence. Cars are not allowed inside the historical old town (except with a permit, available from hotels) so park in one of the numerous lots at the edge of the town. Be warned that the lots fill up quickly in late summer, the height of the tourist season.
Buses, departing from Piazza Pietro Nenni, connect Montepulciano with many other Tuscan cities: Siena (75 minutes, 4/day none on Sunday), Pienza (30 minutes, 8/day), Montalcino (1 hour 10/day, change in Torrenien) and Chiusi (hourly). Route #146 into Montepulciano is quite scenic.
The nearest railhead is a half hour away at Chiusi from where there are frequent trains to Florence and Rome.
The only way to get around is to walk along the steep pathways