The northern region and center of Esquipulas is located within the geographical area known as Region Ch'orti ' of Guatemala. Chorti culture and the Kingdom Payaki or Payaqui which was notable for leaving some of their old architectures developed within this municipality.
Culture Chorti
The first settlers were descendants from Maya people of Copán (archaeological site) Copán, Honduras who came to these lands, shortly after they were forming groups or ethnic groups including ethnic Ch'orti ', these moved Esquipulas after leaving or moving of its ancient cities, this culture achievement develop for several years, even after of the Spanish conquest these were gradually disappearing from the municipality and moved to other municipality such as Camotan, Chiquimula and Jocotan, although they reached the Valley of Esquipulas, this culture is developed more in the villages Timushan and Chanmagua.
Kingdom Payaqui Siglo XVI
Another ethnic group who lived in this municipality was ethnically Payaqui. The priest Topiltzín Axcitl or Nacxit was the founder of the Kingdom Payaqui. The origin of this town, is located in the depths of the mystery of the cultura maya (the name Isquitzuchil´ appears in the history from the earliest times in 1,000 BC).
Spanish colonization
After the arrival of the Spaniards to Guatemala in South Mexico from 1523, they arrived at Esquipulas in 1525, which were found with the Chorti of the area inhabitants, they lived with the Chorti people and imposed all non-believers Catholic doctrine, settled South of the Valley of the Monte Cristo and it was there where they founded the village of Yzquipulas. They formed a system of streets that ran from the main church which
