ught the intercepting fleet were friendly Romans, but scattered upon realizing they were facing an attack by their Macedonian enemy, some choosing to abandon ship and swim to Erythrae. Others, crashing their ships into land on Chios, fled toward the city.
The Chians however closed their gates, startled at the calamity. And the Macedonians, who had docked closer to the city anyway, cut the rest of the fleet off outside the city gates, and on the road leading to the city. Of the 1,000 men, 800 were killed, 200 taken prisoner.'
After the Roman conquest Chios became part of the province of Asia.
Middle Ages
After the permanent division of the Roman Empire in 395 AD, Chios was for six centuries part of the Byzantine Empire. This came to an end when the island was briefly held (1090–97) by Tzachas, a Turkish bey in the region of Smyrna during the first expansion of the Turks to the Aegean coast. However, the Turks were driven back from the Aegean coast by the First Crusade, and the island reverted to Byzantine rule.
This relative stability was ended by the sacking of Constantinople during the Fourth Crusade (1204) and during the turmoil of the 13th century the island ownership was constantly affected by the regional power struggles.
After the Fourth Crusade, the Byzantine empire was divided up by the Latin emperors of Constantinople, with Chios nominally becoming a possession of the Republic of Venice. However, defeats for the Latin empire resulted in the island reverting to Byzantine rule in 1225.
Genoese period (1261–1566)
The Byzantine rulers had little influence and through the Treaty of Nymphaeum, authority was ceded to the Republic of Genoa (1261). At this time the island was frequently attacked by pirates, and by 1302–1303 was a target for the renewed Turkish fleets. To prevent Turkish expansion, the island was reconquered and kept as a renewable concession, at the behest of the Byzantine
