An early mention of Shire is in one of the three surviving charters of Emperor Dawit I of Ethiopia (r. 1382-1412).
As part of the Second Italo-Abyssinian War, Italian units under General Pietro Badoglio advanced out of Axum on 29 February 1936 to attack the Ethiopian army under Ras Imru Haile Selassie deployed around Shire in an action known as the Battle of Shire. Despite determined Ethiopian resistance, by 3 March the Italians had resumed their advance and shortly afterwards crossed theTekez� River.
After the restoration of the monarchy in 1941, Shire served as the capital of the Shire sub-region until the administrative reorganization of the nation following the adoption of the 1995 Ethiopian Constitution. Shire once again became a battlefield during the Ethiopian Civil War, until the Tigrayan People's Liberation Front (TPLF) ejected the government forces in March 1988. The third edition of Lonely Planet guide to Ethiopia notes that "war relics" could still be seen near Shire.
The first clash of the TPLF with government forces occurred 5 August 1975, after Mehari Tekle ("Mussie"), a member of the TPLF leadership, was arrested in Addi Daero by government militiamen and taken to prison in Shire. Before he could be transported to a more secure facility in Mek'ele or Addis Ababa, a squad of eleven men burst into the prison, wounded one policeman scattered the rest, freed their comrade and 60 other prisoners, and spirited him away to safety.
Shire also played a major role in the later part of the Ethiopian Civil War. Following the massive Ethiopian defeat at the Battle of Afabet in March 1988, the TPLF launched a series of offensives, in which they destroyed government forces stationed at Rama, Adwa, Seleh Leha, and Shire. Only about 200 soldiers of the 17th Army Division were able to evacuate Shire and fall back to Gondar. This led to the raising of the Third Revolutionary Army, composed of the 603rd, 604th and 605th core armies. Between
