Phan Rang-Tháp Chàm is located at the junction of National Routes 1A and 27; the former connects the town to Hanoi towards the north and Hồ Chí Minh City to the southwest, while the latter crosses into the Central Highlands towards Buôn Ma Thuột.
The city is connected to the North-South Railway at Tháp Chàm Railway Station; express passenger trains (SE1/2, SE5/6) stop regularly at the station. The station once served as a terminus for the Đà Lạt–Tháp Chàm Railway, a rack railway which opened in 1932. The railway was abandoned during the Vietnam War and dismantled after the North Vietnamese victory in 1975, to provide materials for the restoration of the heavily damaged North-South line. A proposed renewal project, backed by provincial and local governments, aims to restore the entire Đà Lạt–Tháp Chàm railway to handle both passenger and cargo transportation