Gl�nat's Swiss subsidiary has its headquarters in Nyon. Cantor Fitzgerald has an office in Nyon.
As of 2010, Nyon had an unemployment rate of 6%. As of 2008, there were 49 people employed in the primary economic sector and about 13 businesses involved in this sector. 1,331 people were employed in the secondary sector and there were 153 businesses in this sector. 10,644 people were employed in the tertiary sector, with 1,131 businesses in this sector. There were 8,631 residents of the municipality who were employed in some capacity, of which females made up 46.0% of the workforce.
In 2008 the total number of full-time equivalent jobs was 10,337. The number of jobs in the primary sector was 39, of which 35 were in agriculture, 2 were in forestry or lumber production and 2 were in fishing or fisheries. The number of jobs in the secondary sector was 1,264 of which 600 or (47.5%) were in manufacturing and 588 (46.5%) were in construction. The number of jobs in the tertiary sector was 9,034. In the tertiary sector; 1,592 or 17.6% were in the sale or repair of motor vehicles, 281 or 3.1% were in the movement and storage of goods, 493 or 5.5% were in a hotel or restaurant, 400 or 4.4% were in the information industry, 1,414 or 15.7% were the insurance or financial industry, 1,499 or 16.6% were technical professionals or scientists, 595 or 6.6% were in education and 1,150 or 12.7% were in health care.
In 2000, there were 7,415 workers who commuted into the municipality and 5,234 workers who commuted away. The municipality is a net importer of workers, with about 1.4 workers entering the municipality for every one leaving. About 12.1% of the workforce coming into Nyon are coming from outside Switzerland, while 0.1% of the locals commute out of Switzerland for work. Of the working population, 26.7% used public transportation to get to work, and 50.6% used a private car
