Boat
Its possible to travel by boat south from Iquitos on the Rio Ucayali all year round and possibly north from Puerto Bermudez or other ports along the Rio Pachitea depending on the time of year and river height. It's also possible to come from the south, nearly all the way from Cusco by smaller boats along the Urubamba and Ucayali river.
Bus
Buses from Lima take about 18 hours or more (about S/.50 - S/.100; "Transmar" and other companies). Be aware that there a two streets called 28 de Julio in Lima. One in central Lima (there is Transmar) and one in Miaflores (no Transmar there).
Car
The road past Huanuco is very foggy at times, with little visibility. Past Tingo Maria landslides have devastated the road in sections, you can get through but its muddy and slow going in small sections
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