By plane
Fly directly into Guaymas airport from Phoenix or fly into the state capitol of Hermosillo (125 kms. away from Guaymas) and take a bus (Tufesa) from the Hermosillo airport to Guaymas.
By bus
The cost of the bus varies by company and service. Costs range from 50 pesos from Ciudad Obregon and Hermosillo by 2nd class service. Luxury services TAP and Tumesa stops on the the main road in town, Serdan, close to the where it reconnects with Garcia Lopez, the main highway between Culiacan and Hermosillo. The rest of the buses including Estrella Blanca Group cluster around Calle 14 just a few blocks south of Serdan. This bus station open 24 hours a day.
By boat
The Guaymas-Santa Rosalia Ferry conects the Baja California peninsula every day between Guaymas in Sonora and Santa Rosalia in Baja California. This is very useful as people in Los Cabos or La Paz can go to mainland Mexico (and backwards) without having to take a flight or driving as far to the Colorado delta. Notice that you can take your vehicle with you in the boat. The ferry runs from Guaymas to the Baja at night and arrives in the morning to Santa Rosalia, returns to Guaymas and arrives there in the afternoon
