Guanajuato International Airport (IATA: BJX) (ICAO: MMLO) in Silao is the closest airport serving Guanajuato. It also serves the cities of Leon and Silao, the industrial cities of the state. International airlines serving this airport include Aeromexico (Los Angeles CA, Ontario CA), American Eagle (Dallas, TX), Continental Airlines (Houston, TX), Delta Airlines (Atlanta, GA) and Mexicana (Chicago, IL; Los Angeles, CA, Oakland, CA, Sacramento, CA, San Jose, CA). Airlines serving this airport domestically to many cities across Mexico include: Aeromexico, Vivaerobus y Volaris. Alternatively if you're flying from Europe, Asia or South America you can fly through Mexico City and take a bus or a flight from there. The bus ride is around 5 hours. You may also consider Queretaro International Airport QRO some 3 hours from Guanajuato.
By bus
Bus service in Mexico is quite reliable and comfortable. Before the recent start-up of several low cost air carriers, Bus was the main mean of transport across Mexico. Several lines serve Guanajuato including Primera plus. Buses have air conditioning (except some "economy" ones), and often show movies and have refreshments.
You can take a taxi or local bus in the city to the bus station (Central de Autobuses in Spanish) to catch a bus to San Miguel de Allende (1 hour), Guadalajara (3 hours), Mexico City Norte (5 hours), Acapulco,Queretaro and other locations
