National Highway 5 serves the major towns of Sullurpeta, Naidupeta, Gudur, Nellore, Kovur and Kavali in the district. The nearest international airport is at Chennai, 170 km to the south.
The national railway runs throughout the length of the district. Nellore is situated between Gudur Junction and Vijayawada Junction on the Chennai–Vijayawada main line.
On 30 July 2012, at least 25 people were killed when fire, thought to have been caused by an electrical short circuit, swept through a train in Nellore. At least 22 others were injured and needed hospital treatment
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