Plzeň was first mentioned as a castle in 976, as the scene of a battle between Duke Boleslaus II the Pious of Bohemia and Emperor Otto II. It became a town in 1295 when King Wenceslaus II granted Plzeň its civic charter as a special "Royal City" and established a new town site, located some 10 km away from the original settlement, which is the current town of Starý Plzenec. It quickly became an important town on trade routes leading to Nuremberg and Regensburg; in the 14th century, it was the third-largest town in Bohemia after Prague and Kutná Hora. During the Hussite Wars, it was the centre of Catholic resistance to the Hussites: Prokop the Great unsuccessfully besieged it three times, and it joined the league of Catholic nobles against King George of Podebrady. In 1468, the town acquired a printing press; the Troyan Chronicle, the first book published in Bohemia, was printed on it.
Emperor Rudolf II made Plzeň his seat from 1599–1600. During the Thirty Years' War the town was taken by Mansfeld in 1618 after the Siege of Plzeň and it was not recaptured by the Imperial troops until 1621. Wallenstein made it his winter quarters in 1633. The town was unsuccessfully besieged by the Swedes in 1637 and 1648. The town and region have been staunchly Catholic despite the Hussite Wars.
At the end of the 17th century, the architecture of Plzeň began to be influenced by the Baroque style. The city centre has been under cultural heritage preservation since 1989.
In the second half of the 19th century Plzeň, already an important trade centre for Bohemia, near the Bavarian/German border, began to rapidly industrialise. In 1869 Emil Škoda started up the Škoda Works, which became the most important and influential engineering company in the country and a crucial supplier of arms to the Austro-Hungarian Army. By 1917 the Škoda Works employed over 30,000 workers. The second largest employer in this period was, after 1898, the National Railways
