Mayarí is a municipality and city in the Holguín Province of Cuba.
The origins of the city date back to 1757, when the first farms were established on the actual location. On January 19, 1879 the city became the seat of the municipality.
The Sierra Cristal National Park (Spanish: Parque Nacional Sierra Cristal) is partly located in the Mayarí municipality and partly in neighboring Sagua de Tánamo. Other attractions include Cayo Saetia, a cay located north of Mayarí and the Bay of Nipe.
The name of the town figures in the famous song of the 1940s, "Voy para Mayari" by Compay Segundo, and in his song from the Buena Vista Social Club, "Chan Chan"