Kampong Cham features road links with most major Cambodian cities, including Phnom Penh. The highway between Kampong Cham city and the capital Phnom Penh runs along the Mekong, and buses frequent this route daily, so you should have no trouble getting between the two cities.
Car
The National Highway 7 from Kampong Cham to Skun is in excellent condition and one of the best in Cambodia. Shortly after Skun however, the quality changes dramatically with frequent potholes and sometimes not even paved anymore. There is also a new alternative route to Phnom Penh east of the Mekong.
When travelling to/from Siem Reap, it may be worth taking the way via Skun too due to the better quality of the road instead of the road 71 shortcut.
Bus
To get from Phnom Penh to Kampong Cham, there are several options for buses. The standard rules for bussing apply here, and try taking as early a bus as possible, to avoid arriving close to or after dusk, where your choice of accommodation will be limited. The telephone numbers listed here are for locations in Phnom Penh.
When departing from Kampong Cham, bus stations tend to be found near the roundabout on the main road in the city center. One is southwest of the roundabout, on the right side. You buy your ticket at the counter.
Bus Hoh Wa Genting Approximately 7,000 riel, with buses leaving throughout the day at 7:30, 8:10, 9:00, 10:00, 12:30, 14:00, 15:00, 16:00 for a 3-4 hour trip.
GST Express, on the west end of the boulevard,
Rith Mony, on Highway 7 about 200 m from the Mekong bridge roundabout, has buses to a couple of destinations including Kratie and Phnom Penh. It is generally a bit cheaper than other bus companies but the buses are also a bit older.
Capitol, US$4, runs two daily busses leaving Kampong Cham also near Highway
