following the Fourth Crusade, the Byzantine Empire fragmented, and Butrint falling to the breakaway Despotate of Epirus. In the following centuries, the area was a site of conflict between the Byzantines, the Angevins of southern Italy, and the Venetians, and the city changed hands many times. In 1267, Charles of Anjou took control of both Buthrotum and Corfu leading to further restorations of the walls and the Great Basilica.
The Republic of Venice purchased the area including Corfu from the Angevins in 1386; however, the Venetian merchants were principally interested in Corfu and Buthrotum once again declined. By 1572 the wars between Venice and the Ottoman Empire had left Buthrotum ruinous and at the order of Domenico Foscarini, the Venetian commander of Corfu, the administration of Buthrotum and its environs was shifted to a small triangular fortress associated with the extensive fish weirs. The area was lightly settled afterwards, occasionally being seized by the Ottoman Turks, in 1655 and 1718, before being recaptured by the Venetians. Its fisheries were a vital contributor to the supply of Corfu, and olive growing together with cattle and timber were the principal economic activities.
Modern
In 1797, Butrint came under French control when Venice ceded it to Napoleon as a part of the Treaty of Campo Formio. In 1799, the local Ottoman governor Ali Pasha Tepelena conquered it, and it became a part of the empire until Albanian independence in 1912. By that time, the site of the original city had been unoccupied for centuries and was surrounded by malarial marshes
